Table II. Dysregulated microRNAs following surgical resection of metastatic melanoma with top target pathway.
Plasma microRNA analysis via NanoString was performed in 6 individuals with solitary melanoma metastasis before and after complete surgical resection. Differentially expressed miRs (P<0.05) are listed with their respective targets. Top target pathways were identified using ToppFunn functional enrichment analysis.
| miRNA | Mean Fold Change | Top Pathway Enriched |
|---|---|---|
| miR-let-7a | 0.36 | Cyclins and cell cycle regulation |
| miR-let7g | 0.47 | P53 signaling pathway |
| miR-15a | 0.48 | Pathways in cancer |
| miR-16 | 0.31 | Adaptive Immune System |
| miR-22 | 1.20 | Regulation of nuclear SMAD2/3 signaling |
| miR-30b | 0.54 | Pre-NOTCH expression and processing |
| miR-126 | 0.48 | mTOR signaling pathway |
| miR-140 | 1.00 | Pathways in cancer |
| miR-145 | 0.45 | TGF-beta signaling pathway |
| miR-148a | 0.61 | Post-transcriptional silencing by small RNAs |
| miR-150-5p | 0.26 | Pre-NOTCH transcription and translation |
| miR-191 | 0.59 | Coregulation of androgen receptor activity |
| miR-378i | 1.10 | - |
| miR-449c | 0.54 | Telomeres, telomerase, cellular aging, and immortality |
| miR-494 | 0.66 | Insulin/IGF pathway-protein kinase B signaling cascade |
| miR-513b | 1.15 | - |
| miR-548aa | 1.13 | - |
| miR-571 | 1.08 | P53 pathway |
| miR-587 | 1.02 | - |
| miR-891b | 0.94 | Ca2+ pathway |
| miR-1260a | 1.77 | - |
| miR-1268a | 1.24 | Transcription factor CREB and its extracellular signals |
| miR-1976 | 0.42 | - |
| miR-4286 | 1.27 | - |