Fig. 4.

Voltage-gated K⁺ current (K_v) in colon-projecting DRG neurons in sham and BO (day 7) rats. (A) Representative traces of K_v in sham and BO rats, with the I_total in the left, the I_K in the center of the panel, and the I_A in the right. For total K_V current (I_total), the membrane potential was held at −100 mV and voltage steps were from −40 to +30 mV with 5-mV increments and 400-ms duration. For sustained K_v current (I_K), the membrane potential was held at −50 mV and the voltage steps were the same as above. Currents generated by these two protocols were subtracted to produce I_A. Bar graphs of the mean peak K_v density of DRG neurons from sham and BO rats were displayed in B for I_total, in C for I_K, and in D for I_A currents. The current density (in pA/pF) was calculated by dividing the current amplitude by cell membrane capacitance. N= 30 neurons (5 rats) in sham and 31 neurons (6 rats) in BO. *p < 0.05 vs. sham.