Table 1.
Serotonergic Drug List Categorized by Similar Bioactive Sites of Action
| Drug Name | Category | Drug Name | Category |
|---|---|---|---|
| Amitriptylinea | Triple receptor | Selegiline | MAO inhibitor |
| Amoxapine | Triple receptor | Tranylcypromine | MAO inhibitor |
| Citaloprama | Triple receptor | Dihydroergotamine | 5‐HT1 agonists |
| Clomipraminea | Triple receptor | Eletriptan | 5‐HT1 agonists |
| Cyclobenzaprinea | Triple receptor | Frovatriptan | 5‐HT1 agonists |
| Cyproheptadine | Triple receptor | Pentazocine | 5‐HT1 agonists |
| Desipraminea | Triple receptor | Rizatriptan | 5‐HT1 agonists |
| Doxepina | Triple receptor | Sumatriptan | 5‐HT1 agonists |
| Fluoxetinea | Triple receptor | Zolmitriptan | 5‐HT1 agonists |
| Imipraminea | Triple receptor | Almotriptan | Mixed SERT |
| Mirtazapine | Triple receptor | Dextromethorphana | Mixed SERT |
| Nortriptyline | Triple receptor | Granisetron | Mixed SERT |
| Meperidinea | Triple receptor | Lorcaserin | Mixed SERT |
| Paroxetinea | Triple receptor | Naratriptan | Mixed SERT |
| Protriptyline | Triple receptor | Trazodone | Mixed SERT |
| Sertraline | Triple receptor | Vilazodone | Mixed SERT |
| Trimipramine | Triple receptor | Buspironea | Miscellaneous |
| Atomoxetinea | Duo receptor | Carbamazepine | Miscellaneous |
| Desvenlafaxinea | Duo receptor | Divalproex | Miscellaneous |
| Duloxetinea | Duo receptor | Lithium | Miscellaneous |
| Escitaloprama | Duo receptor | Ondansetrona | Miscellaneous |
| Fluvoxaminea | Duo receptor | Metoclopramide | Miscellaneous |
| Levomilnacipran | Duo receptor | Valproate | Miscellaneous |
| Maprotiline | Duo receptor | Valproic Acid | Miscellaneous |
| Methadonea | Duo receptor | Aripiprazolea | Atypical antipsychotic |
| Milnacipran | Duo receptor | Asenapine | Atypical antipsychotic |
| Nefazodone | Duo receptor | Brexpiprazole | Atypical antipsychotic |
| Tramadola | Duo receptor | Clozapinea | Atypical antipsychotic |
| Venlafaxinea | Duo receptor | Iloperidone | Atypical antipsychotic |
| Fentanyla | MAO inhibitor | Lurasidone | Atypical antipsychotic |
| Isocarboxazid | MAO inhibitor | Olanzapine | Atypical antipsychotic |
| Linezolid | MAO inhibitor | Paliperidone | Atypical antipsychotic |
| Methylene Blue | MAO inhibitor | Quetiapine | Atypical antipsychotic |
| Phenelzine | MAO inhibitor | Risperidonea | Atypical antipsychotic |
| Rasagiline | MAO inhibitor | Vortioxetine | Atypical antipsychotic |
| Ziprasidone | Atypical antipsychotic |
5‐HT1 = 5‐hydroxytryptamine receptor; MAO = monoamine oxidase; SERT = serotonin reuptake protein.
See Methods for description of pharmacologic drug categories.
a
Data taken from Flockhart P450 drug interaction table.42 Other listed drugs may also undergo hepatic metabolism but are less well documented.