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. Author manuscript; available in PMC: 2018 Oct 5.
Published in final edited form as: Leukemia. 2018 Mar 27;32(10):2224–2239. doi: 10.1038/s41375-018-0044-x

Figure 4. BET-specific PROTACs affect cell cycle regulation and the Akt/mTOR pathway.

Figure 4

The effect of ARV-825 or ARV-763 on the expression levels of proteins are shown from reverse phase protein array (RPPA) analysis (Supplementary Figure 6) of MM1.S (top panel) or RPMI 8226 (bottom panel) cells. These were treated with either 100 nM ARV-825 or 250 nM ARV-763 for 24 hours prior to preparation for analysis. Normalized linear values of antibody signal representing levels of BRD4 and c-MYC, and of proteins involved in cell cycle regulation and the Akt/mTOR pathway, are plotted as means ± SD from triplicate experiments.