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. Author manuscript; available in PMC: 2018 Oct 5.
Published in final edited form as: Leukemia. 2018 Mar 27;32(10):2224–2239. doi: 10.1038/s41375-018-0044-x

Figure 5. Influence of PROTACs on Akt and mTOR pathway signaling.

Figure 5

The effect of ARV-825 or ARV-763 on the expression levels of key intermediates in the PI3K-Akt-mTOR pathway signaling were probed by Western blotting of MM1.S (left panel) and RPMI 8226 (right panel) cells. These were exposed for 24 hours to the indicated drug concentrations prior to harvesting and preparation of cell lysates for analysis.