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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Burns. 2018 Mar 27;44(7):1738–1749. doi: 10.1016/j.burns.2018.02.029

Figure 1. Human IgM and IgG antibody binding to pig and human aortic endothelial cells (AECs) by flow cytometry.

Figure 1

Human IgM (a) and IgG (b) binding to GTKO/hCD46 pig AECs was significantly decreased compared with wild-type (WT) pig AECs (*P<0.05), and was further decreased to GTKO/hCD46/NeuGcKO pig AECs (*P<0.05). There was significantly greater IgM binding to GTKO/hCD46/NeuGcKO pig AECs than human AECs (‡P<0.05), but there was no statistical significance of the extent of IgG binding between them. (MFI=mean fluorescence intensity; ns=not significant.) (Reproduced with permission from Wijkstrom M, et al. Kidney Int. 2017;91:790–796.)