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. 2018 Mar 1;9(10):879–889. doi: 10.1007/s13238-018-0510-2

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Proposed models for the context-dependent roles of β-TRCP in regulating the Wnt signaling. (A) Under Wnt off conditions, β-TRCP formed a degradation complex to recognize and degrade CKIα/GSK3-mediated phosphorylated form of β-catenin, to repress β-catenin targeted genes, and maintain Wnt in silent status. (B) Under Wnt on conditions, the activated FZD/LRP5/6 receptor destructs β-catenin degradation complex and releases β-catenin downstream targeted genes. Simultaneously, as a feedback regulator of Wnt pathway, ZNRF3 degrades FZD to alleviate Wnt signal. Meantime, β-TRCP1 could promote the degradation of CKI-mediated phosphorylated form of ZNRF3, to sustain the Wnt pathway