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. 2017 Jul 14;9(10):838–847. doi: 10.1007/s13238-017-0440-4

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Release of CRP and cytokines at scheduled time points and occasional time points from patients’ peripheral blood since the enrollment of CART-HER2 cell therapy. (A) Change of CRP during the CART-HER2 cell therapy. (B) The level of IL-6 release monitored according to the study flowchart. (C) Release of interleukin-2 (IL-2). (D) Fluctuation of interleukin-8 (IL-8) following the treatment of CART-HER2 cell infusion. (E) Interleukin-10 (IL-10) detected after the CART-HER2 cell treatment. (F) Release of tumor necrosis factor-α (TNF-α)