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. 2018 Sep 27;8:14480. doi: 10.1038/s41598-018-32755-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increases in activated and atypical memory B cells occur in M.tb infection and correlate with improved mycobacterial control. B cell subsets were characterised among patients with active TB disease (n = 19), LTBI (n = 18) and healthy controls (n = 9) before starting anti-TB treatment. The proportions of mature (A), naïve (B), classical (C), activated (D) and atypical (E) B cells are shown. Negative correlations between the proportion of activated (F) and atypical (G) B cells and BCG net growth were seen. Points are single values and bars represent the median with interquartile range. After testing for normality a Kruskal-Wallis test with Dunn’s correction for multiple comparisons was performed. *Represents a p-value of <0.05, **a p-value of <0.005, ***a p-value of <0.0005 and ****a p-value of <0.0001. Spearman’s rho and associated p-values are shown.