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. 2018 Sep 27;8:14480. doi: 10.1038/s41598-018-32755-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum cytokine analysis reveals discrete clusters, which delineate the spectrum of M.tb infection and strong negative correlations with ex vivo mycobacterial growth. Serum cytokine/chemokine responses in pre-treatment samples from active TB (n = 20), LTBI (n = 83) and healthy control individuals (n = 30) were investigated by Luminex assay. A heatmap of cytokine/chemokine levels (log, row scaled, pg/ml) is shown. Samples were clustered according to Spearman correlation distance and the four most distinct clusters were coloured in black, grey, blue and red. For clustering of cytokines/chemokines into three clusters, k-means clustering was applied to the rows.