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. 2018 Sep 27;8:14475. doi: 10.1038/s41598-018-32837-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In silico functional study on the regulatory potential of the deletion at 6p22.1. Schematic representation of the locus containing the deletion region associated with asthma in Brazilian populations (expanded view: 6:29,801,381–30,018,756; RefSeq: GRCh38). This region was cross-referenced with DNA sequence annotations, including: location of protein coding or non-protein coding genes (GENCODE 26); presence of large structural variations identified by the 1000 genomes project, phase 3 (SV – 1KG 3); position of putative regulatory elements (regulatory build); location of constrained elements for 40 eutherian mammals (GERP, Genomic Evolutionary Rate Profiling); presence of SNPs and short indels associated with any human phenotype in previous studies. Limits of the deletions found in samples from Salvador or Pelotas are symbolized by a yellow or a green bar, respectively. Image created using the Ensembl genome browser (http://www.ensembl.org).