Table 3.
A deletion region located in the locus 6p22.1 is associated with asthma in two independent Brazilian populations.
| CNVR | CNVR class | CNVR size (bp) | Freq. Case | Freq. Ctrl | OR | 95% CI | p | Power |
|---|---|---|---|---|---|---|---|---|
| Salvador, Brazil (Discovery) | ||||||||
| 6:29,889,788–29,931,412 | Deletion | 41,624 | 6.6 | 2.4 | 3.0 | 1.7–5.2 | 2 × 10 −4 | 0.902 |
| Pelotas, Brazil (Replication) | ||||||||
| 6:29,881,842–29,931,412 | Deletion | 49,570 | 4.0 | 1.6 | 1.9 | 1.2–2.8 | 4 × 10 −3 | 0.837 |
| Random-effects meta-analysis | ||||||||
| OR | p | |||||||
| 2.3 | 3 × 10 −6 | |||||||
CNVR: Copy number variation region, chromosome:start-end; bp: base pair; Frequency of CNVR (%); Case: asthmatic; Ctrl: non-asthmatic; OR, odds ratio; SE, SE of odds ratio (OR); 95% CI, 95% confidence interval; p, p value (additive model). The significance threshold established for the discovery phase was p ≤ 3.4 × 10−4; The significance level applied in the replication study was p = 0.05; Power: A posteriori statistical power.
Covariates in multivariate analysis: sex, age, Log2 of R ratio standard deviation (LRRSD) and principal components (PC1, PC2 and PC3).
Human genome assembly: GRCh38.