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. 2018 Sep 27;8:14451. doi: 10.1038/s41598-018-32668-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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slc15a4 contributes to IMQ driven cytokine storm. Inflammatory cytokine plasma concentrations were measured following IMQ treatment using a 25-cytokine luminex assay. Fold changes (IMQ-treated at the indicated timepoint/time = 0) are shown at 24 hours (A) and 5 days (B). Cytokines were rank-ordered for IMQ-induction in WT. The dotted line represents where IMQ treatment does not affect circulating cytokine levels. The ratio of IMQ-induced fold changes are displayed in blue (decreased), red (increased) and black (<1.5x changed) comparing mutant to WT. Data was combined from three independent experiments with a total of 5–13 mice per group. *p < 0.05 in unpaired T-test after multiple comparison correction.