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. 2018 Sep 27;8:14457. doi: 10.1038/s41598-018-32780-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Generation and identification of PON1^−/− rats using the CRISPR/Cas9 system. (a) Schematic overview of the strategy used to generate PON1^−/− rats. (b) RT-PCR analysis of PON1 mRNA levels in the liver, spleen and thymus of 2-month-old PON1^−/− and PON1^+/+ rats. (c) Western blot analysis of PON1 protein levels in the liver, spleen and thymus of 2-month-old PON1^−/− and PON1^+/+ rats. (d) Immunohistochemical analysis of PON1 expression in the cortex and medulla of the thymus in 2-month-old PON1^−/− and PON1^+/+ rats. GAPDH expression was used for normalization. Scale bar = 20 μm.