Fig. 3.

Causal estimates of blood lipid level-increase due to genetic variants in genes encoding drug targets. Inverse variance-weighted (black) and MR Egger (gray) instrumental variable estimates using genome-wide significantly associated variants within 100 b either side of the gene in low linkage disequilibrium (r² < 0.4). Analyses take correlations between genetic instruments into account. Causal estimates express the change in odds ratio (OR) per standard deviation (SD) increment in lipid concentration. Error bars indicate 95% confidence intervals