Table 2.
Top 10 genes with the greatest increase/decrease in expression induced by SDSE-167 injection in db/+ and db/db mice.
| Increase in db/db and db/+ |
Decrease in db/db and db/+ |
Increase in db/db specifically |
Decrease in db/db specifically |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Log (Fold Change) |
Log (Fold Change) |
Log (Fold Change) |
Log (Fold Change) |
||||||
| Gene | db/db | m+/db | Gene | db/db | m+/db | Gene | db/db | Gene | db/db |
| Gm10309 | 10.0 | 10.0 | C630028N24Rik | –8.0 | –1.6 | Ptgs2 | 6.8 | Gm4794 | –3.0 |
| Ripk2 | 10.0 | 2.2 | Per3 | –4.9 | –2.4 | Il1b | 4.5 | 1600002H07Rik | –2.8 |
| Il33 | 10.0 | 1.9 | Pck1 | –4.6 | –1.6 | Fgf23 | 4.4 | Arhgef19 | –2.7 |
| Rnd1 | 10.0 | 3.5 | Fmo2 | –3.6 | –1.4 | Il6 | 3.8 | Mtnr1a | –2.7 |
| Tnfaip3 | 10.0 | 10.0 | Rxrg | –3.5 | –1.8 | Nos2 | 3.8 | Ptprb | –2.6 |
| Selp | 10.0 | 3.1 | Olfml1 | –3.2 | –2.9 | Gbp3 | 3.7 | Sdpr | –2.5 |
| Reg3g | 10.0 | 10.0 | Lyst | –3.2 | –1.3 | Ctla2a | 3.4 | 4732463B04Rik | –2.4 |
| Slc7a6 | 10.0 | 4.0 | Dbp | –3.2 | –3.4 | Tmem154 | 3.3 | Smpd3 | –2.4 |
| Serpine1 | 10.0 | 10.0 | Slc46a3 | –3.1 | –2.5 | Clec4e | 3.1 | Dnajc28 | –2.4 |
| Cxcl2 | 9.2 | 3.1 | Slc16a12 | –3.0 | –4.1 | Car13 | 2.9 | Zmat1 | –2.4 |