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. 2018 Sep 21;9:2137. doi: 10.3389/fimmu.2018.02137

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Copyright © 2018 Braga Filho, Abreu, Rios, Trovão, Silva, Cysne, Nascimento, Fortes, Silva, Guerra, Maciel, Serezani and Nascimento.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of simvastatin pretreatment on the recruitment and activation of peritoneal cells. Animals received water (CLP group) or simvastatin (Simvastatin group) orally for 30 days when CLP was induced. (A) Total and differential cell counts were made 12 h after the CLP. (B) Release of H₂O₂, spontaneous and induced by PMA, into the peritoneum of animals with sepsis induced by CLP. The results represent the mean ± S.D. of 5 animals per group. The Naïve group received no procedures and the Sham group was submitted to all the procedures with exception of cecum perforation. *p < 0.05 compared to the CLP group. ^#p < 0.05 when compared to the Naïve and Sham groups.