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. 2018 Sep 21;9:1025. doi: 10.3389/fphar.2018.01025

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Copyright © 2018 Bai, Tang, Chuang, Wang and Hong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DOX-SPIO/NPCS microparticle suspension effectively suppressed hepatic cancer cell proliferation at concentrations of 0.5–50 μg/mL as compared to that of free form of DOX: (A) free form of DOX, and (B) DOX-SPIO/NPCS microparticle suspension. The same concentration of free DOX was also tested simultaneously for comparison. All cell viabilities shown in this figure are normalized to the negative control (NC) group treated with equivalent amounts of serum-free DMEM medium. n = 3 was tested for each group of trial. **p < 0.01 and ***p < 0.001, respectively.