Table 2.

Gray matter and white matter volume reductions in SCA2 patients relative to healthy controls

Regions	No. of voxels	Maximum MNI coordinates (x, y, z)	SDM‐Z value	p Value	Clusters’ breakdown (no. of voxels >50)	Jackknife sensitivity
GM: Cerebellar hemisphere/cerebellar vermis/R fusiform gyrus	9745	12, −60, −20	−3.902	0.000	R cerebellar hemispheric lobule III‐VIII, Crus I/II	5 out of 5
					R fusiform gyrus	5 out of 5
					Cerebellar vermis (lobule IV‐IX)	5 out of 5
					L cerebellar hemispheric lobule IV/V	5 out of 5
					R parahippocampal gyrus	5 out of 5
					R lingual gyrus	4 out of 5
WM: Middle cerebellar peduncles/Cortico‐spinal projections/R Cerebellar hemisphere/pons	3498	30, −52, −34	−6.547	0.000	Middle cerebellar peduncles	4 out of 4
					R cortico‐spinal projections	4 out of 4
					R cerebellar hemispheric lobule III‐VIII, Crus I/II	4 out of 4
					Cerebellar vermis (lobule III)	3 out of 4
					L cortico‐spinal projections	4 out of 4
					Pons	4 out of 4
Middle cerebellar peduncles/L cerebellar hemispheric	1632	−28, −54, −38	−2.624	0.000	Middle cerebellar peduncles	3 out of 4
					L cerebellar hemispheric lobule VI, Crus I/II	4 out of 4

GM: gray matter; L: left; No: number; R: right; SCA2: spinocerebellar ataxia type 2; SDM: seed‐based d mapping; WM: white matter.