Table 2.
Treatment‐induced sparing. Anatomic location of areas of reduced gray matter loss in estriol + glatiramer acetate (GA) cohort compared to placebo + GA cohort after 12 months of treatment
| Anatomic structure | MNI coordinates | Cluster size (voxels) | Cluster size (ml) | Z score | ||
|---|---|---|---|---|---|---|
| X | Y | Z | ||||
| Left frontal cortex | −22 | 14 | 48 | 3,382 | 11.4 | 4.68 |
| Medial parietal cortex | 4 | −7 | 64 | 2,203 | 7.4 | 4.61 |
| Left parietal cortex | −44 | −46 | 46 | 1,817 | 6.1 | 4.12 |
| Medial frontal cortex | −2 | 38 | 36 | 1,393 | 4.7 | 4.43 |
| Left parietal cortex | −60 | −22 | 31 | 731 | 2.5 | 4.23 |
| Right temporal cortex | 56 | 0 | 9 | 642 | 2.2 | 4.29 |
| Medial parietal cortex | 4 | −51 | 12 | 490 | 1.7 | 4.16 |
| Medial occipital cortex | 3 | −64 | −3 | 297 | 1.0 | 4.19 |
MNI, coordinates (x, y, z) according to Montreal Neurological Institute space.