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. 2018 Aug 24;8(9):e01086. doi: 10.1002/brb3.1086

Table 4.

Pearson's correlation coefficients between absolute change in treatment‐induced sparing volume and the absolute change in MRI and clinical measurements

Specific clinical measurements All (111) Estriol + GA (62) Placebo + GA (49)
Whole GM volume 0.84*** 0.89*** 0.77***
Cortical GM volume 0.53*** 0.54*** 0.46***
WM volume −0.23 * −0.27* −0.21
CSF volume −0.59*** −0.65*** −0.51***
Gd‐enhancing lesion volume −0.03 −0.07 0.11
FLAIR lesion volume 0.03 0.04 −0.13
PASAT3 0.20* 0.31* −0.34*
PASAT2 0.31** 0.34** 0.08
9HPT −0.09 −0.21 0.09
T25FW −0.01 0.06 −0.19
MSFC 0.15 0.22 −0.06
EDSS 0.02 0.02 0.03

CSF, cerebrospinal fluid; EDSS, expanded disability status scale; FLAIR, fluid‐attenuated inversion recovery; GA, glatiramer acetate; Gd, gadolinium; GM, gray matter; MRI, magnetic resonance imaging; MSFC, multiple sclerosis functional composite; PASAT2, paced auditory serial addition test at 2 s; PASAT3, paced auditory serial addition test at 3 s; T25FW, timed 25‐foot walk; WM, white matter; 9HPT, 9‐hole peg test.

*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.