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Development of intracranial volume (ICV) in CLN5 sheep. ICV development of CLN5 − / − and CLN5+/- sheep between 3 and 19 months (mo). (a) Mean ICV ±SEM at different ages (* indicating significance at p ≤ 0.05). (b) Mean accumulative ICV gain or loss (± SEM, dotted lines) from 3 mo of age. CLN5+/-: 3 mo n = 3; 5–17 mo n = 6; 19 mo n = 3. CLN5 − / −: 3 mo n = 3; 5–17 mo n = 6; 19 mo n = 2
