Table 2.

Uni- and multivariate predictors of primary end event.

Variable	All-cause death				Cardiovascular death
	Univariate		Multivariate		Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Age	1.08 (1.04–1.12)	<0.01	1.07 (1.02–1.11)	<0.01	1.05 (1.01–1.10)	0.02	1.2 (0.47–3.51)	0.47
Male sex	1.62 (0.72–3.62)	0.24			0.71 (0.27–1.85)	0.48
CVD	5.61 (2.46–12.78)	<0.01	2.42 (1.05–5.59)	0.04	3.01 (1.20–7.54)	0.02	1.77 (0.66–4.70)	0.61
Hypertension	1.72 (0.68–4.36)	0.26			1.34 (0.51–3.53)	0.56
Heart rate	1.03 (1.02–1.04)	<0.01	1.03 (1.02–1.04)	<0.01	1.02 (1.01–1.04)	<0.01	1.01 (0.997–1.03)	0.12
QTc	0.98 (0.92–1.003)	0.41			1.00 (0.99–1.01)	0.87
CKMB	1.00 (0.99–1.01)	0.57			1.00 (0.99–1.02)	0.43
HCY	0.97 (0.88–1.06)	0.51			1.00 (0.95–1.06)	0.93
Statin use	0.63 (0.28–1.41)	0.26			1.46 (0.53–4.03)	0.47
QT prolongation > 450 ms	2.28 (1.02–5.08)	0.04	1.09 (0.45–2.65)	0.85	4.36 (1.73–10.97)	0.04	2.76 (1.05–7.22)	0.04
Negative T in lead II	1.50 (0.49–4.57)	0.48			1.92 (0.62–5.92)	0.35
Negative T in lead V6	1.76 (0.78–3.97)	0.18			1.94 (0.79–4.76)	0.15
ST depression	1.19 (0.51–2.79)	0.69			1.76 (0.73–4.24)	0.21
Upright TaVR	6.10 (2.39–15.53)	<0.01	2.88 (1.07–7.73)	0.04	4.65 (1.77–12.24)	<0.01	3.04 (1.07–8.64)	0.04

Parameters with a P value < 0.05 were entered in the multivariate analysis.

Upright TaVR was defined as T-wave with a positive deflection ≥ 0 mV in lead aVR.

HR: hazard ratio; CI: confidence interval; CVD: cardiovascular disease; QTc: rate-corrected QT; CKMB: creatine kinase MB; HCY: homocysteine; TaVR: T wave in lead aVR.