Table 1.

List of known SPOP substrates

SPOP Substrates
Protein Name	Protein Function
MacroH2.A	Chromatin Organization / Accessibility
PDX1	Insulin / Glucose Transport
Daxx	Transcription Repression / Apoptosis regulation
ERa	Hormone Signaling / Growth / Development
HHIP	Hedgehog Signaling / Development
Gli2/3	Hedgehog Signaling / Development
SRC3	Hormone Signaling
AR	Hormone Signaling / Growth / Development
SUFU	Hedgehog Signaling / Development
DUSP7	Tyrosine Phosphotase / Multiple Pathways
PTEN	Phosphotase / Metabolism
DDIT3	ER Stress
DEK	mRNA Processing
ERG	Transcription factor Multiple Pathways
SENP7	Senescence
PR	Hormone Signaling / Growth / Development
TRIM24	Transcriptional Control of Nuclear Receptors / Multiple Pathways
SETD2	Epigenetic Regulation
CDC20	Cell Cycle Regulation
Sirt2	Deacetylase
EgIN2	Oxygen Response
C-Myc	Transcription Factor / Multiple Pathways
INF2	Mitochondrial Dynamics
HDAC6	Epigenetic Regulation
BRD4	Chromatin Reader
PDL1	Apoptosis / Immune Response
MMP2	ECM regulation