Table 3.

Hazard ratio for overall survival and different patient groups stratified by gender, age, tumor stage, and tumor sites according to WHO body mass index (patients with normal weight were used as the reference group)

Category, HR (95% CI)	Underweight (BMI <18.5 kg/m2)	Normal weight (BMI 18.5~25 kg/m2)	Overweight (BMI 25-30 kg/m2)	Moderately obese (BMI 30~35 kg/m2)	Severely obese (BMI > 35 kg/m2)
Overall cohort	2.19 (2.03-2.36)**	1	0.68 (0.64-0.72)**	0.48 (0.42-0.55)**	0.48 (0.36-0.63)**
Male	2.16 (1.97-2.37)**	1	0.61 (0.56-0.65)**	0.43 (0.36-0.52)**	0.55 (0.37-0.80)*
Female	2.31 (2.02-2.63)**	1	0.87 (0.80-0.95)*	0.63 (0.52-0.77)**	0.53 (0.35-0.80)*
Age <70	2.49 (2.28-2.72)**	1	0.69 (0.64-0.74)**	0.46 (0.39-0.54)**	0.51 (0.37-0.70)**
Age ≥70	1.74 (1.47-2.06)**	1	0.64 (0.57-0.72)**	0.58 (0.44-0.75)**	0.74 (0.39-1.43)
Tumor stage: Local	2.40 (2.12-2.71)**	1	0.71 (0.65-0.78)**	0.58 (0.48-0.70)**	0.49 (0.32-0.74)*
Tumor stage: Regional	1.98 (1.76-2.24)**	1	0.68 (0.61-0.74)**	0.39 (0.31-0.50)**	0.45 (0.26-0.77)*
Tumor stage: Distant	1.62 (1.32-1.98)**	1	0.73 (0.61-0.86)**	0.59 (0.40-0.87)*	0.55 (0.25-1.23)
Tumor stage: Unclassified	1.49 (1.17-1.90)*	1	0.67 (0.57-0.79)**	0.37 (0.24-0.58)**	0.77 (0.37-1.62)
Tumor site: Breast or thyroid	1.51 (0.92-2.48)	1	0.99 (0.80-1.25)	0.73 (0.46-1.14)	0.66 (0.24-1.76)
Tumor site: CRC + GYN +GU	1.85 (1.60-2.13)**	1	0.70 (0.64-0.77)**	0.54 (0.44-0.67)**	0.71 (0.49-1.04)
Tumor site: HN, esophagus, thorax, and others	2.34 (2.07-2.64)**	1	0.69 (0.62-0.76)**	0.44 (0.34-0.57)**	0.19 (0.08-0.45)**
Tumor site: HBP, stomach, Small bowel	2.05 (1.77-2.37)**	1	0.67 (0.59-0.75)**	0.55 (0.41-0.74)**	0.70 (0.38-1.31)
Tumor site: CNS	0.67 (0.40-1.13)	1	0.67 (0.51-0.88)*	0.57 (0.29-1.11)	0.37 (0.09-1.48)

CRC, colorectal cancer; GYN, gynecology; GU, genitourinary; HN, head and neck; HPB, hepato-biliary-pancreatic; CNS, central nervous system; BMI, body mass index

(* indicated P<0.01, ** indicated P<0.001)