Table 1.
Characteristics of studies included in this meta-analysis
| Study | Country | Year | Cancer type | MicroRNA-497 expression | MicroRNA-497 assay | HR statistic | HR (95%CI) high/low | Survival analysis | NOS | Cut-off value | Follow-up (months) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| High | Low | ||||||||||||||||
| Total | LNM | Ⅲ/Ⅳ | Total | LNM | Ⅲ/Ⅳ | ||||||||||||
| Wang 19 | China | 2014 | OC | 38 | 17 | 27 | 58 | 40 | 38 | qRT-PCR | Survival curve | 0.92 (0.42-2.01) | Univariate | 8 | - | 60 | |
| Li 21 | China | 2014 | GC | 48 | 22 | 24 | 49 | 36 | 30 | qRT-PCR | Survival curve | 0.37 (0.20-0.68) | Univariate | 8 | Median value | 60 | |
| Zhao 23 | China | 2015 | ccRCC | 38 | 2 | 8 | 48 | 11 | 26 | qRT-PCR | Date in paper | 0.39 (0.16-0.59) | Multivariate | 8 | Mean level | 60 | |
| Katharina 24 | Austria | 2015 | DLBCL | 29 | - | 16 | 29 | - | 17 | qRT-PCR | Date in paper | 0.36 (0.12-1.01) | Univariate | 7 | Median value | 120 | |
| Huang 25 | China | 2015 | NSCLC | 25 | 7 | - | 26 | 13 | - | qRT-PCR | Survival curve | 0.44 (0.22-0.91) | Univariate | 7 | Median value | 60 | |
| Zhang 26 | China | 2016 | HCC | 43 | - | 4 | 43 | - | 15 | qRT-PCR | Date in paper | 0.47 (0.28-0.81) | Multivariate | 7 | Median value | 60 | |
| Pang 27 | China | 2016 | OS | 94 | - | 20 | 91 | - | 54 | qRT-PCR | Date in paper | 0.26 (0.12-0.50) | Multivariate | 7 | Median value | 70 | |
| Feng 29 | China | 2016 | Gliomas | 52 | - | 16 | 58 | - | 48 | qRT-PCR | Date in paper | 0.30 (0.14-0.91) | Multivariate | 7 | Median value | 60 | |
| Song 28 | China | 2017 | OS | 19 | - | 3 | 27 | - | 16 | qRT-PCR | - | - | - | 6 | Mean level | 72 | |
| Liu 22 | China | 2017 | GC | 38 | - | 17 | 48 | - | 34 | qRT-PCR | - | - | - | 6 | Mean level | - | |
| Wang 30 | China | 2017 | TC | 21 | 1 | 2 | 27 | 14 | 15 | qRT-PCR | - | - | - | 7 | Mean level | - | |
| Sun 31 | China | 2017 | RCC | 14 | 1 | 2 | 26 | 12 | 10 | qRT-PCR | - | - | - | 7 | - | - | |
Note: The dashes mean no data.
III/IV: TNM stage III/IV; LNM: lymph node metastasis; OC: ovarian cancer; GC: gastric cancer; ccRCC: clear cell renal cell carcinoma; DLBL: diffuse large B-Cell lymphoma; NSCLC: non-small cell lung cancer; HCC: hepatocellular carcinoma; OS: osteosarcoma; TC: thyroid cancer; RCC: renal cell carcinoma