Table 1.
Clinicopathological characteristics in relation to F2RL3 expression status.
| Variable | Entire group (n=367) | F2RL3 mRNA expression | F2RL3 IHC expression | |||||
|---|---|---|---|---|---|---|---|---|
| Low expression (n=91) | Middle expression (n=147) | High expression (n=129) | P valuea | Negative (n=114) | Positive (n=253) | P valueb | ||
| Age at surgery (y, mean±SD) | 55.3±11.7 | 55.4±12.7 | 55.1±11.3 | 55.4±11.5 | 0.969 | 55.9±12.3 | 55.0±11.4 | 0.483 |
| Sex (n, %) | 0.980 | 0.464 | ||||||
| Male | 248 (67.6) | 61 (67.0) | 99 (67.3) | 88 (68.2) | 74 (64.9) | 174 (68.8) | ||
| Female | 119 (32.4) | 30 (33.0) | 48 (32.7) | 41 (31.8) | 40 (35.1) | 79 (31.2) | ||
| Smoking (n, %) | 0.013 | 0.033 | ||||||
| No | 163 (44.4) | 35 (38.5) | 79 (53.7) | 49 (38.0) | 60 (52.6) | 103 (40.7) | ||
| Yes | 204 (55.6) | 56 (61.5) | 68 (46.3) | 80 (62.0) | 54 (47.4) | 150 (59.3) | ||
| Clinical manifestation (n, %) | 0.729 | 0.562 | ||||||
| Incidental | 246 (67.0) | 60 (65.9) | 102 (69.4) | 84 (65.1) | 74 (64.9) | 172 (68.0) | ||
| Symptomatic | 121 (33.0) | 31 (34.1) | 45 (30.6) | 45 (34.9) | 40 (35.1) | 81 (32.0) | ||
| Laterality (n, %) | 0.902 | 0.425 | ||||||
| Left | 182 (49.6) | 44 (48.4) | 72 (49.0) | 66 (51.2) | 53 (46.5) | 129 (51.0) | ||
| Right | 185 (50.4) | 47 (51.6) | 75 (51.0) | 63 (48.8) | 61 (53.5) | 124 (49.0) | ||
| Tumor size (cm, mean±SD) | 5.2±2.4 | 4.9±2.6 | 5.1±2.5 | 5.5±2.2 | 0.197 | 4.8±2.6 | 5.3±2.3 | 0.064 |
| T stage at presentation (n, %) | <0.001 | <0.001 | ||||||
| T1-T2 | 300 (81.7) | 84 (92.3) | 127 (86.4) | 89 (69.0) | 105 (92.1) | 195 (77.1) | ||
| T3-T4 | 67 (18.3) | 7 (7.7) | 20 (13.6) | 40 (31.0) | 9 (7.9) | 58 (22.9) | ||
| N stage at presentation (n, %) | 0.004 | 0.002 | ||||||
| N0 | 326 (88.8) | 84 (92.3) | 137 (93.2) | 105 (81.4) | 110 (96.5) | 216 ( 85.4) | ||
| N1 | 41 (11.2) | 7 (7.7) | 10 (6.8) | 24 (18.6) | 4 (3.5) | 37 (14.6) | ||
| M stage at presentation (n, %) | 0.015 | 0.001 | ||||||
| M0 | 330 (89.9) | 85 (93.4) | 137 (93.2) | 108 (83.7) | 111 (97.4) | 219 (86.6) | ||
| M1 | 37 (10.1) | 6 (6.6) | 10 (6.8) | 21 (16.3) | 3 (2.6) | 34 (13.4) | ||
| ISUP grade (n, %) | <0.001 | <0.001 | ||||||
| 1-2 | 175 (47.7) | 63 (69.2) | 73 (49.7) | 39 (30.2) | 75 (65.8) | 100 (39.5) | ||
| 3-4 | 192 (52.3) | 28 (30.8) | 74 (50.3) | 90 (69.8) | 39 (34.2) | 153 (60.5) | ||
aP velue for F2RL3 mRNA expression
bP velue for F2RL3 IHC expression