Table 3.
Univariate and multivariate Cox regression analyses of OS in 367 enrolled ccRCC patients
| Univariate analysis | Multivariate analysisa | Multivariate analysisb | ||||||
|---|---|---|---|---|---|---|---|---|
| Covariates | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | ||
| Age at surgery | 1.018 (1.004-1.033) | 0.012 | 1.014 (0.999-1.029) | 0.068 | 1.013 (0.998-1.029) | 0.086 | ||
| Sex (male vs. female) | 0.922 (0.639-1.331) | 0.665 | 1.015 (0.635-1.622) | 0.952 | 1.028 (0.642-1.646) | 0.908 | ||
| Smoking (No vs. Yes) | 1.046 (0.745-1.470) | 0.794 | 0.968 (0.628-1.493) | 0.884 | 0.985 (0.641-1.516) | 0.947 | ||
| Clinical manifestation (incidental vs. symptomatic) | 0.968 (0.674-1.391) | 0.861 | 0.951 (0.654-1.382) | 0.791 | 0.951 (0.653-1.384) | 0.793 | ||
| Laterality (left vs. right) | 1.030 (0.735-1.443) | 0.866 | 0.914 (0.645-1.295) | 0.613 | 0.938 (0.662-1.329) | 0.719 | ||
| Tumor size | 0.995 (0.928-1.067) | 0.890 | 1.004 (0.931-1.082) | 0.923 | 1.010 (0.938-1.088) | 0.792 | ||
| T stage (T1-T2 vs. T3-T4) | 12.148 (8.359-17.654) | <0.001 | 1.651 (1.060-2.573) | 0.027 | 1.737 (1.120-2.694) | 0.014 | ||
| N stage (N0 vs. N1) | 12.684 (8.352-19.264) | <0.001 | 3.147 (1.777-5.571) | <0.001 | 2.972 (1.674-5.276) | <0.001 | ||
| M stage (M0 vs. M1) | 11.554 (7.618-17.525) | <0.001 | 5.456 (3.377-8.813) | <0.001 | 5.858 (3.640-9.428) | <0.001 | ||
| ISUP grade (1-2 vs. 3-4) | 3.466 (2.364-5.038) | <0.001 | 1.658 (0.938-2.930) | 0.082 | 1.612 (0.909-2.858) | 0.102 | ||
| F2RL3 mRNA expression (Low vs. middle) | 1.473 (0.875-2.479) | 0.145 | 1.497 (0.889-2.520) | 0.129 | - | - | ||
| F2RL3 mRNA expression (low vs. high) | 2.826 (1.713-4.662) | <0.001 | 2.936 (1.777-4.851) | <0.001 | - | - | ||
| F2RL3 IHC expression (negative vs. positive) | 1.712 (1.140-2.569) | 0.009 | - | - | 1.811 (1.203-2.725) | 0.004 | ||
aMultivariate model include F2RL3 mRNA expression and covariates.
bMultivariate model include F2RL3 IHC expression and covariates.