Table 1.
Characteristics of patients included in the three cohorts.
| Cohort 1, (O'Brien et al., 2014) | Cohort 2, (unpublished) | Cohort 3, (Fumery et al., 2017) | ||
|---|---|---|---|---|
| All participants | n = 65 | n = 62 | n = 211 | |
| Disease status | CD UC No-IBD controls |
52% 12% 35% |
27% 24% 48% |
100% 0% 0% |
| Gender | Males | 60% | 53% | 45% |
| Age (year) | Median (interquartile range) | 45.1 (23–95)a | 23.6 (9.5–62)b | 33.8 (25–70)b |
| Smoking habits | Never smokers Past smokers Active smokers |
NA | 58% 21% 21% |
38% 28% 34% |
| Genotyping |
NOD2 wt NOD2 mutated* |
68% 32% |
89% 11% |
56% 44% |
|
ATG16L1 (AA) ATG16L1 (AG + GG) |
18% 82% |
29% 70% |
21% 79% |
|
|
IRGM (CC) IRGM (CT + TT) |
85% 15% |
74% 26% |
62% 38% |
|
| CD patients only | n = 34 | n = 17 | n = 211 | |
| Age at diagnosis | A1 (< 17 years) A2 (17–40 years) A3 (>40 years) |
16% 59% 25% |
55% 45% 0% |
10% 80% 10% |
| Disease Location | L1 (ileum) L2 (colon) L3 (ileocolon) L4 (upper gastrointestinal) |
59% 13% 25% 3% |
20% 50% 30% 0% |
60% 1% 38% 2% |
| Disease Behavior | B1 (inflamatory) B2 (stricturing) B3 (penetrating) |
6% 72% 22% |
80% 0% 20% |
16% 48% 36% |
CD, Crohn's Disease; UC, Ulcerative Colitis; IBD, Inflammatory Bowel Disease;
a
at diagnosis;
b
at enrolment;
*
one or more of the R702W, G908R, or L1007fs-insC mutations.
Cohort 1 and 3: post-surgical resected tissues, cohort 2: endoscopic mucosal biopsies.
Montreal Classification is reported for CD patients (Satsangi et al., 2006).