Table 1.
Trans-synaptic molecules, their partner proteins, and associated proteases involved in synaptic function.
| Family | Molecule | Transsynaptic partner and type of iteraction | Reference | Complex-associated extracellural proteases | Reference |
|---|---|---|---|---|---|
| Neuroligin | Neuroligin-1 neuroligin-2 neuroligin-3 neuroligin-4 | β-Neurexin (direct interaction) | Ichtchenko et al., 1995, 1996; Gangwar et al., 2017 | MMP-9 ADAM10 |
Peixoto et al., 2012; Suzuki et al., 2012 |
| Cadherin | N-cadherin | N-cadherin (direct interaction) neuroligin-1 (through a S-SCAM protein) |
Stan et al., 2010; Aiga et al., 2011 | ADAM10 MT5-MMP calpain |
Covault et al., 1991; Monea et al., 2006; Jang et al., 2009; Malinverno et al., 2010 |
| Eph receptor | EphA1-10 receptors EphB1-5 receptors | EphrinA (direct interaction) ephrinB (direct interaction) | Klein, 2009; Daar, 2012 | ADAM10 MMP-2 MMP-9 neuropsin |
Hattori et al., 2000; Klein, 2004; Murai and Pasquale, 2004; Lin et al., 2008; Attwood et al., 2011 |
| NCAM | NCAM | NCAM (direct interaction) | Bukalo and Dityatev, 2012 | ADAM17 MMP-2 MMP-9 calpain |
Covault et al., 1991; Kalus et al., 2006; Shichi et al., 2011 |
| Contactins | Contactin-1 Contactin-2 Contactin-3 Contactin-4 Contactin-5 Contactin-6 |
Contactin-1 (direct interaction) Contactin-2 (direct interaction) Contactin-3 (direct interaction) Contactin-4 (direct interaction) Contactin-5 (direct interaction) Contactin-6 (direct interaction) |
Zuko et al., 2013 | _ | _ |
| Contactins | Contactm-3 Contactm-4 Contactin-5 Contactin-6 |
PTPRG (not studied) | Nikolaienko et al., 2016 | _ | _ |
| LRR proteins | NGL-1 NGL-2 |
Netrin-G1 (direct interaction) Netrin-G2 (direct interaction) |
Lin et al., 2003; Kim et al., 2006 | _ | _ |
| LRR proteins | SALMs | SALMs (direct interaction) | Seabold et al., 2008 | _ | _ |
| LRR proteins | LRRTMs | α-neurexin (not studied) β-neurexin (not studied) |
de Wit et al., 2009; Ko et al., 2009; Siddiqui et al., 2010; Südhof, 2017 | _ | _ |
| Dystroglycan | β-Dystroglycan | β-neurexin (through an α-dystrogjycan) | Sugita et al., 2001; Michaluk et al., 2007 | MMP-9 | Michaluk et al., 2007 |
| Neurexophillins | Neurexophillin-1 Neurexophillin-2 Neurexophillin-3 Neurexophillin-4 |
α-neurexm (not studied) | Südhof, 2017; Chamma and Thoumine, 2018 | _ | _ |
| Cerebellins | Cerebellin-1 Cerebellin-2 Cerebellin-3 Cerebellin-4 |
α-neurexin (not studied) β-neurexin (not studied) |
Südhof, 2017; Chamma and Thoumine, 2018 | _ | _ |
| Calsyntenins | Calsyntenins-3 | α-neurexm (not studied) | Südhof, 2017; Chamma and Thoumine, 2018 | _ | _ |