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. 2018 Sep 9;8(17):4781–4794. doi: 10.7150/thno.25189

Figure 5.

Figure 5

RGS4 deficit in the prefrontal cortex impairs pre-pulse inhibition and decreases social interaction. (A) Base startle reactivity in block 1 was significantly higher in RGS4 knockdown mice compared with control mice (n = 12). *P < 0.001 compared to control mice, empty or Stranger 1; # P < 0.01 compared to vehicle-treated mice, one-way ANOVA followed by Tukey's test. (B) The percentage pre-pulse inhibition was significantly lower in RGS4 knockdown mice compared with control mice (n = 12). *P < 0.001 compared to control mice, empty or Stranger 1; # P < 0.05 compared to vehicle-treated mice, two-way ANOVA followed by Bonferroni test. RGS4 knockdown mice failed to demonstrate a preference for social proximity (C) and social novelty (D) by spending the same amount of time in both chambers. All the behavior tests were carried out at 21 days after virus injection. For the NAC treatment, mice were pre-treated with NAC (500 mg/kg/day) or vehicle for 1 week before behavior tests. N = 12 per group. *P < 0.001 compared to empty or Stranger 1; # P < 0.001 compared to vehicle-treated mice, two-way ANOVA followed by Bonferroni test.