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. 2018 Sep 9;8(17):4633–4648. doi: 10.7150/thno.26687

Figure 4.

Figure 4

The anti-metastasis effect of Amlexanox acts through the IKKɛ/TBK1/NF-κB signaling axis. (A-B) GSEA analysis of RNA-seq data indicates downregulation of metastasis-associated signature genes and increased expression of genes in the NF-κB signaling pathway in Amlexanox-treated PC3 cells. (C) KEGG analysis of RNA-seq data from PC3 cells treated with Amlexanox or vehicle. (D) PC3-clone 4 displays a higher activation of IKKɛ/TBK1/NF-κB pathway. (E) Amlexanox treatment inhibits activation of the NF-κB pathway and induces MET.