Table 2.
Statistical analysis of tumor volume and volumetric vascular density growth curves for each dose group. Significant differences were observed only in TV doubling time immediately post-treatment. Treated tumors experienced delayed tumor growth (increased TV doubling time) immediately after treatment. There were no other statistically significant growth curve trends between treated and untreated, and local control and local failure tumors.
| Untreated | All Treated | 15 Gy | 20 Gy | 25 Gy | ||||
|---|---|---|---|---|---|---|---|---|
| Local Control | Local Failure | Local Control | Local Failure | Local Control | Local Failure | |||
| TV Doubling time - Initial Response (days) | 1.9 ± 0.5 | 3.8 ± 2.6 (p=0.009) |
5.6 ± 3.4 | 3.4 ± 0.5 | 2.4 ± 1.4 | |||
| 5.5 ± 1.2 | 5.7 ± 4.7 | 3.6 ± 0.7 | 3.3 ± 0.3 | 2.3 ± 1.3 | 2.4 ± 1.9 | |||
| VVD increase - Initial Response (%) |
39.1 ± 105.0 | 32.8 ± 39.1 |
33.2 ± 26.9 | 85.6 ± 62.6 | 11.7 ± 21.9 | |||
| 36.8 ± 47.6 | 31.1 ± 10.9 | 62.2 ± 117.3 | 101.3 ± 7.6 | 17.2 ± 25.9 | 7.0 ± 22.6 | |||
| TV Halving time - Regression (days) | ~ | 3.0 ± 1.0 | 3.2 ± 0.7 | 2.8 ± 0.3 | 2.9 ± 1.4 | |||
| 2.5 ± 0.3 | 3.8 ± 0.5 | 3.0 ± 0.6 | 2.7 ± 0.1 | 2.1 ± 0.3 | 1.3 ± 1.6 | |||
| VVD Regression (%) | ~ | -20.4 ± 30.6 | -8.1 ± 33.0 | -49.0 ± 8.6 | --13.3 ± 27.8 | |||
| -25.2 ± 28.0 | -1.3 ± 35.1 | -55.0 ± 9.1 | -45.0 ± 6.8 | --15.2 ± 26.6 | --10.2 ± 35.6 | |||
| TV Doubling time - Recurrence (days) | ~ | 4.7 ± 2.1 | 3.6 ± 0.8 | 6.4 ± 3.4 | 4.5 ± 1.2 | |||
| VVD - Recurrence (%) | ~ | 26.6 ± 73.6 | -13.4 ± 68.0 | 100.7 ± 71.0 | 19.0 ± 22.5 | |||