Figure 9.

(mean ± SD, n = 3) (a) Top panels: Permeation profiles of clobetasol propionate and (b) Bottom panels: Amount of drug recovered from nail or bovine hoof after the eleven days of permeation study. In both cases, the left panels show the results for bovine hoof and the right panels the results obtained with human nail clippings. In both models, the lacquer made with 5% Poloxamer 407 and a 1:1 water:ethanol mixture and the reference lacquer containing 8% of clobetasol propionate in Uñabase (see text and Material and Methods) were compared. Stars indicates significant differences with the other lacquers (two-way ANOVA, Tukey post-hoc test, α < 0.05).