Ae0–24h
|
the percentage of the dose excreted in the urine during 24 h |
AUC |
area under the plasma concentration–time curve |
CL |
time-averaged total body clearance |
CLNR
|
time-averaged nonrenal clearance |
CLR
|
time-averaged renal clearance |
Cmax
|
maximum plasma concentration |
F |
the extent of absolute oral bioavailability |
fu
|
unbound fraction |
GI24 h
|
the percentage of the dose recovered from the gastrointestinal tract at 24 h (including their contents and feces during 24 h) |
IMP |
imperatorin |
IS |
internal standard |
LC-MS/MS |
liquid chromatographic–tandem mass spectrometry |
LLOQ |
lower limit of quantification |
MRT |
mean residence time |
PA |
paeonol |
PKs |
pharmacokinetics |
SD |
standard deviation |
SSa |
saikosaponin a |
Tmax
|
time to reach Cmax
|
Vss
|
apparent volume of distribution at steady state |