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Characterization summary of 40:60 CDP146 ASDs produced by spray-drying (100 mg).
| ASD Composition | Yield | Miscibility/Solid State | |||
|---|---|---|---|---|---|
| Polymer | DL (w/w) | Yield (%) | Tg (°C) | Tm (°C) | XRPD Pattern/PLM |
| HPMCP HP50 | 40% | 68.1 | 113.5 | - | A |
| HPMCAS-LF | 40% | 70.9 | 102.5 | - | A |
| Eudragit L100 | 40% | 71.8 | 163.4 | - | A |
| Eudragit L100-55 | 40% | 71.7 | 120.9 | - | A |
A: amorphous sample characterized by the presence of a large halo in XRPD and the absence of birefringence under PLM observations.
