Table 1.

Pharmacokinetic parameters of methyl 3-amino-6-methoxythieno [2,3-b] quinolone-2-carboxylate (PU-48) after single oral administration of PU-48 SNEDDS at the doses of 3, 6 and 12 mg/kg in rats plasma (mean ± SD, n = 6).

Pharmacokinetic Parameters	Unit	PU-48
		3 mg/kg	6 mg/kg	12 mg/kg
C max	ng/mL	12.6 ± 11.1	52.9 ± 46.8	94.3 ± 49.6
T max	h	1.19 ± 0.94	0.63 ± 0.31	0.50 ± 0.27
AUC0–t	ng·h/mL	60.0 ± 38.3	106.8 ± 53.0	178.9 ± 60.1
AUC0–∞	ng·h/mL	60.5 ± 38.5	108.2 ± 52.5	180.7 ± 62.5
t 1/2	h	7.14 ± 2.93	7.00 ± 2.70	6.87 ± 3.49

C_max, maximum concentration; T_max, peak time; t_1/2, half life time; AUC_0–t, area under curve from time zero to the time of last quantifiable concentration; AUC_0–∞, area under curve from time zero to infinity.