Table 2.
Tissue distribution-time course after single oral administration of methyl 3-amino-6-methoxythieno [2,3-b] quinolone-2-carboxylate (PU-48) SNEDDS (12 mg/kg) in rats (n = 6, mean ± SD).
| Tissues | Concentration of PU-48 (ng/mL or ng/g) | ||||
|---|---|---|---|---|---|
| 0.5 h | 1 h | 6 h | 12 h | 24 h | |
| Plasma | 276.7 ± 42.4 | 119.1 ± 63.5 | 16.8 ± 26.4 | 2.4 ± 1.7 | 0.3 ± 0.1 |
| Liver | 622.2 ± 182.8 | 534.3 ± 228.4 | 42.7 ± 27.3 | 13.4 ± 3.1 | 20.4 ± 12.2 |
| Spleen | 265.9 ± 120.1 | 161.2 ± 64.0 | 15.2 ± 12.9 | 3.8 ± 5.7 | 9.9 ± 12.0 |
| Lung | 231.0 ± 79.3 | 174.3 ± 91.4 | 7.2 ± 5.7 | 0.9 ± 0.1 | 1.3 ± 0.9 |
| Kidney | 415.8 ± 137.7 | 296.6 ± 241.4 | 44.5 ± 33.9 | 4.7 ± 1.1 | 5.3 ± 3.4 |
| Heart | 251.1 ± 78.4 | 124.6 ± 31.0 | 11.3 ± 11.2 | ND | 0.5 |
| Muscle | 39.8 ± 28.6 | 52.0 ± 25.5 | 4.5 ± 3.5 | 2.0 ± 1.9 | 1.4 ± 1.5 |
| Colon | 90.4 ± 30.0 | 172.5 ± 89.5 | 35.2 ± 14.7 | 28.6 ± 21.7 | 14.1 ± 5.6 |
| Intestine | 654.8 ± 89.3 | 777.4 ± 277.3 | 209.3 ± 166.5 | 45.4 ± 18.9 | 9.0 ± 4.7 |
| Stomach | 887.3 ± 234.9 | 2017.8 ± 821.5 | 508.8 ± 160.5 | 104.0 ± 28.4 | 7.0 ± 3.1 |
| Bladder | 258.2 ± 94.2 | 367.7 ± 123.8 | 43.4 ± 10.7 | 6.1 ± 3.2 | 8.6 ± 6.5 |
| Testicle | 34.2 ± 21.2 | 51.7 ± 24.4 | 9.5 ± 8.5 | 1.5 ± 0.7 | 1.4 ± 1.1 |
| Fat | 480.6 ± 398.1 | 99.3 ± 26.9 | 52.3 ± 43.2 | 2.7 ± 1.9 | 0.7 ± 0.6 |
| Brain | 111.1 ± 23.3 | 68.1 ± 52.7 | 15.7 ± 19.3 | 1.7 ± 1.5 | ND |
ND: not detected.