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. 2018 Sep 15;8(3):51. doi: 10.3390/metabo8030051

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The ‘dark side’ of Human metabolism. The least covered subgraph of Recon 2.03 obtained from LPA using mapping status as the initial state. White circles: Non-mapped metabolites. Blue circles: mapped metabolites. Edges: Substrate-product relationships. Metabolites with ambiguous identifier have been removed. Colored Hulls: Pathways overrepresented in the poorly mapped area of the human metabolic network Recon 2.03. Right-tailed Fisher exact test with Benjamini-Hochberg correction, α = 0.05.