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Three-dimensional (3-D) space-filling models of one of the author’s developed aptamers using YASARA [21] to analyze the accessibility of potentially inflammatory CpG sequences and alterations to the 3-D structure of the putative binding site (left) once it is excised from the complete aptamer (right). The figure also summarizes a list of approaches to evaluating and rectifying potential CpG toxicity problems. PEG = polyethylene glycol.
