Table 1. Rate-Limiting Steps (Membrane Entry, Flip–Flop, or Membrane Exit) for Membrane Permeation Depending on the Steroid Structure and the Type of Membrane.
cell | planar membrane | LUV (radius 0.2 μm) | |
---|---|---|---|
long-tailed | exit | exit | exit |
0–1 OH groups | entry | entry | exit |
2–3 OH groups | flip–flop | flip–flop | flip–flop |