Table 1.

Effects of selected chemical components of Glycyrrhiza species on CYP450 enzyme inhibition [16,18].

Extract	Cytochrome P450 iso-enzymes 1
	1A2	2A6	2B6	2C8	2C9	2C19	2D6	2E1	3A4
18β-Glycyrrhetinic acid	+	+	+	++	+	+	+	+	++
Glabridin	+	+	+	++	+	+	+	+	++
Glycycoumarin	++	+	++	+++	+++	+++	++	+	+
Isoliquiritigen	+	+	+	+++	+++	+	+	++	++
Licochalcone A	++	+	+	+++	+++	+++	++	++	++
Licoricidin	+	+	+++	+++	+++	+++	++	++	++

¹ + = weak inhibition, ++ = moderate inhibition and +++ = strong inhibition.