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Generation of Bisphosphonate-Bortezomib (BP-Btz) conjugate. (A) Diagram showing the principle of our bone targeting strategy, including a bisphosphonate, a linker, and a payload that usually is a drug or other pharmacological inhibitor. (B) Steps of the BP-Btz synthesis. (C) Molecular weight and chemical formulation of BP-Btz, Btz or BP-linker.
