Figure 3. . Caenorhabditis elegans survival assays after infection with fungal pathogens.

(A) CAPE and compound 14 are capable of significantly increasing Candida albicans-infected nematode survival. (B) pak-1 is involved in the immune response to C. albicans in a liquid-killing assay. Two independently generated fer-15;pak-1 nematodes were significantly more susceptible to C. albicans infection when compared with fer-15 nematodes. (C) pak-1 is involved in the immune response to C. albicans in a solid killing assay. Two independently generated fer-15;pak-1 nematodes were significantly more susceptible to C. albicans infection when compared with fer-15 nematodes. (D) pak-1 is involved in the immune response to Cryptococcus neoformans. fer-15;pak-1 nematodes were significantly more susceptible to C. neoformans infection when compared with fer-15 nematodes.

CAPE: Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester.