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. 2018 Sep 7;8(3):50. doi: 10.3390/metabo8030050

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Contribution plot and performance of 9 common subacute TBI biomarkers classifying the PD/PPD subjects from PD controls. (a) Note prominence of the Glutamic Acid contribution, but with relative abundance values reduced in PD/PDD and compared to controls. (b) Respectable performance (ROC AUC = 0.8488) of 9 member panel in classifying PD/PDD subjects from controls. Comp = PLS-DA model component. TBI = traumatic brain injury. PD = Parkinson’s disease. PDD = PD dementia. ROC AUC = receiver operating characteristic area under the curve. PA = Phosphatidic acid. PC = phosphatidylcholine. LysoPC lysophosphatidylcholine. PG = Phosphatidylglycerol. PE = phosphatidylethanolamine. GlcCer = glucosylceramide. S1P = sphingosine-1-phosphate. Final metabolite identifications will require additional tandem mass spectrometry (MS/MS) analyses. Metabolites confirmed via MS/MS are considered fully validated, to a high degree of confidence.