Skip to main content
. 2018 Aug 16;13(10):1141–1156. doi: 10.2217/fmb-2018-0033

Figure 7. . Increased intracellular eactive oxygen species leads to filamentation defects of Candida albicans, and decreasing intracellular reactive oxygen species can rescue the filamentation of sdh2Δ/Δ.

Figure 7. 

Figure 7. 

(A) The sdh2Δ/Δ mutant exhibits significantly increased intracellular reactive oxygen species (ROS). **p < 0.01 compared to the wild-type control group. (B) ROS-inducing agents dose-dependently lead to ROS accumulation in wild-type C. albicans. ROS-inducing agents include H2O2 and menadione. **p < 0.01; ***p < 0.001 compared with the wild-type C. albicans cells without treatment. (C) The ROS-inducing agents inhibit the filamentous growth of C. albicans dose-dependently. (D) Antioxidative vitamin E and proanthocyanidins decreased intracellular ROS of C. albicans. *p < 0.05; **p < 0.01 compared with the group without treatment. #p < 0.05 compared with wild-type C. albicans. (E) The filamentation of sdh2Δ/Δ is rescued by the antioxidants (vitamin E and proanthocyanidins). (F) The filamentation of sdh2Δ/Δ is rescued under both the low oxygen and the anoxia conditions, while efg1Δ/Δ cph1Δ/Δ remains filamentation defective.