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. 2018 Aug 1;6(3):31. doi: 10.3390/proteomes6030031

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Biochemical pathways and functions in brain regions and postsynaptic proteome modules (PPMs). (A) KEGG pathway term (y-axis) enrichment in PPMs (x-axis) with the number of proteins contributing to KEGG enrichment indicated in brackets. Size of the dots represents the number of genes associated with that pathway (GeneRatio) and the significance indicated by the p-adjust color bar. (B) Heatmap of the KEGG biochemical pathway and disease enrichment terms (y-axis) based on the ranked abundance of postsynaptic proteins in each region (x-axis). Three clusters of KEGG terms are boxed: (1) many signal transduction mechanisms; (2) synaptic plasticity and other signaling processes; and (3) neurodegenerative diseases and metabolic mechanisms.

Biochemical pathways and functions in brain regions and postsynaptic proteome modules (PPMs). (A) KEGG pathway term (y-axis) enrichment in PPMs (x-axis) with the number of proteins contributing to KEGG enrichment indicated in brackets. Size of the dots represents the number of genes associated with that pathway (GeneRatio) and the significance indicated by the p-adjust color bar. (B) Heatmap of the KEGG biochemical pathway and disease enrichment terms (y-axis) based on the ranked abundance of postsynaptic proteins in each region (x-axis). Three clusters of KEGG terms are boxed: (1) many signal transduction mechanisms; (2) synaptic plasticity and other signaling processes; and (3) neurodegenerative diseases and metabolic mechanisms.