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. 2018 Sep 3;8(4):2045894018800439. doi: 10.1177/2045894018800439

Fig. 5.

Fig. 5.

(a) Comparison of measured raw (open circles) and averaged (blue dots and bars) right-ventricular end-diastolic and end-systolic pressure-volume relations with computational model predictions. Control: Model-predicted end-diastolic and end-systolic PV relations (squares and gray lines) using control-group geometry and control-matched material properties. PAH1-4: Model-predicted end-diastolic and end-systolic PV relations (squares and gray lines) using control-group geometry and control material properties. Model-predicted end-diastolic and end-systolic PV relations (solid lines) using PAH geometry and control material properties. Model-predicted end-diastolic and end-systolic PV relations (dashed lines) using PAH geometry and PAH-matched material properties. (b) Model-predicted isometric end-systolic and end-diastolic sarcomere length-tension relations for all 5 animal groups determined by optimizing material parameters to match measured RV pressure-volume relations. Note the increase in predicted systolic sarcomere elastance 2–4 weeks after MCT. End-diastolic sarcomere stiffness tension decreases at week 1 of PAH and increases by.