. 2018 Sep 3;8(4):2045894018800439. doi: 10.1177/2045894018800439

Table 1.

Summary statistics of hemodynamics, elastances, and RV structural changes observed during PAH progression.

Parameter	CTL (n = 7)	PAH1 (n = 8)	PAH2 (n = 8)	PAH3 (n = 6)	PAH4 (n = 4)
Fulton Index	0.24 ± 0.04	0.31 ± 0.05	0.34 ± 0.04^*	0.47 ± 0.1^*^,†	0.52 ± 0.03^*^,†,‡
RV weight (g)	0.22 ± 0.04	0.23 ± 0.04	0.3 ± 0	0.37 ± 0.05	0.47 ± 0.05^*^,†
RV thickness (mm)	0.61 ± 0.08	0.59 ± 0.1	0.6 ± 0.08	1.03 ± 0.07^*^,†,‡	1.12 ± 0.12^*^,†,§
Animal's weight (g)	268 ± 23.3	262.1 ± 43.2	293 ± 18.1	267.3 ± 24.6	283.7 ± 24.9
ESP (mmHg)	31.7 ± 6.1	27.3 ± 2.4	39.5 ± 6	52.3 ± 7.3^†	70.5 ± 6.8^*^,†
ESV (µL)	90.8 ± 19.3	79.2 ± 19.3	109.7 ± 37	126.1 ± 25.9	140.9 ± 35.6^†
EF (%)	62.3 ± 6.7	64.2 ± 6.4	61 ± 7.6	53.6 ± 9.9	53.9 ± 5.4
CO (mL/min)	41.2 ± 3.5	40.5 ± 8.4	51.7 ± 10.8	45.9 ± 13.5	45.5 ± 3.4
SV (µL)	149 ± 16.7	141.1 ± 22.9	165.9 ± 24.5	148.3 ± 38.3	160.3 ± 6
dP/dt_max (mmHg/µL)	1603.8 ± 316.2	1492.4 ± 242.4	1933.4 ± 394.8	2082.6 ± 123.9^†	2680.3 ± 311.5^*^,†,‡
HR (bpm)	278.5 ± 26	286.7 ± 40.7	311.2 ± 39.2	307.4 ± 17.5	284.2 ± 23.6
mPAP (mmHg)	24.3 ± 4.9	25.2 ± 2	32.6 ± 4.8^*	34.3 ± 4.6^*	42.8 ± 4.9^*^,†,‡
Total PVR (mmHg/mL.min)	0.8 ± 0.2	0.7 ± 0.2	0.8 ± 0.2	1.2 ± 0.4	1.6 ± 0.2^†
EDP (mmHg)	4.6 ± 0.7	3.5 ± 1.4	4.6 ± 1.4	5.4 ± 2.3	7.7 ± 1.7^†,‡
EDV (µL)	239.7 ± 19.6	220.3 ± 31.6	275.6 ± 49.5	274.4 ± 36.7	301.3 ± 37.8^†
dP/dt_min (mmHg/µL)	−1274 ± 349.4	−1079.2 ± 172.3	−1462.6 ± 308.2	−1876.9 ± 233.7^*^,†	−2080.6 ± 237.7^*^,†,‡
τ (ms)	15.1 ± 3.4	13.6 ± 2.8	14.7 ± 4	12.8 ± 1.4	11.1 ± 3.4
E_es (mmHg/µL)	0.25 ± 0.08	0.25 ± 0.11	0.25 ± 0.09	0.34 ± 0.1	0.45 ± 0.13^*^,†,‡
E_a (mmHg/µL)	0.2 ± 0.06	0.21 ± 0.06	0.24 ± 0.04	0.4 ± 0.16	0.42 ± 0.07^*^,†
E_ed (mmHg/µL)	0.03 ± 0.013	0.015 ± 0.006	0.019 ± 0.011	0.027 ± 0.023	0.033 ± 0.005
η	1.31 ± 0.52	1.25 ± 0.67	1.05 ± 0.39	1.06 ± 0.6	1.11 ± 0.3

P < 0.05 vs. CTL.

^†

P < 0.05 vs. PAH1.

^‡

P < 0.05 vs. PAH2.