Figure 2.

Results of four selected metabolites of three normalization methods of combined and chronotype-stratified analyses as well as pathways potentially affected by night shift work. Plot (A) shows the β-estimates and associated 95% confidence intervals of four metabolites based on creatinine-, osmolality- and regression based normalization of combined and stratified analysis; Plot (B) shows a Venn diagram of significantly altered metabolites when comparing DS with NS in the combined analysis of three normalization methods. Colours indicate the direction of the observed change (red = increase, green = decrease); Plot (C) depicts an overview for pathways potentially affected by night shift work. OCTN2, cell membrane carrier; CACT, Carnitine acylcarnitine translocase; NAD, Nicotinamide adenine dinucleotide (oxidised); NADH, Nicotinamide adenine dinucleotide (deoxidised); NAM, Nicotinamide; NMN, Nicotinamide mononucleotide; NAMPT, nicotinamide phosphoribosyl transferase; NAMPT, Gene encoding NAMPT.